Ethanolic extract of root of Tephrosia purpurea (Linn.) Pers (Fabaceae) at the doses of 100,250 and 500mg/kg were studied for hepatoprotective activity in wistar albino rats of either sex against carbon tetrachloride (1.2 ml/kg intraperitonial) induced hepatotoxicity. Alteration in the levels of biochemical markers of hepatic damage like SGPT,SGOT,ALP, bilirubin (total and direct), cholesterol level, HDL and histopathological changes in the liver were tested in both treated and untreated groups. Carbon tetrachloride (1.2 ml/ intraperitonial) has enhanced the SGPT, SGOT, ALP, bilirubin and cholesterol levels and reduced the serum level of HDL and causes the sevear liver damage. The results revealed that alcoholic extract of T. purpurea root (100, 250 and 500 mg/kg b.wt) has significantly decrease the SGPT, SGOT, ALT, cholesterol level and increase the serum level of HDL.A comparative histopathological study of liver from test groups exhibited almost normal architecture specially with dose of 500mg/kg b.wt, as compared to CCl4 treated group. The observed effects were compared with hepatoprotective agent Silymarin.
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